ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum
This study demonstrated that changes in intracellular ATP content respond to environmental perturbations and impact the biosynthesis of GAs, holding substantial implications for production practices. Modulating ATP levels could increase GAs yields, cater to market demands, and reduce costs. The research also furnishes a scientific foundation for optimizing cultivation conditions, employing genetic engineering to refine biosynthetic pathways, and leveraging environmental control to boost production efficiency.
Authors
- Yufei Lan
- Mingwen Zhao (ORCID: https://orcid.org/0000-0002-9413-1743)
- Sining Yue (ORCID: https://orcid.org/0000-0003-3708-4845)
- Qianqian Cong
- Liang Shi (ORCID: https://orcid.org/0009-0007-5164-1245)
- Weidong Liu (ORCID: https://orcid.org/0000-0001-7954-7700)
- Yin Sun (ORCID: https://orcid.org/0000-0003-2903-5410)
- Yi Kong (ORCID: https://orcid.org/0000-0002-0598-493X)
Institutions
- Nanjing Agricultural University (CN)
- Ministry of Agriculture (FJ)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s12934-025-02668-2
- Citations
- 2
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.79