Correlation between Serum Levels of Thyroid Peroxidase-Antibody and Severity of Acne Vulgaris

The aim of the study was to estimate serum levels of thyroid peroxidase-antibody (TPO-Ab) in individuals with acne vulgaris and subjects who appeared to be healthy, to compare TPO-Ab between the two groups and to correlate severity of acne vulgaris with serum levels of TPO-Ab. A total number of 120 participants of both genders with age range between 15 to 45 years were selected in this study according to inclusion and exclusion criteria. Among them, 60 individuals with acne vulgaris were assigned to group A. Group A was again sub-divided into mild, moderate and severe acne on the basis of the severity of acne vulgaris. For comparison, 60 persons who appeared healthy and were matched by age and gender were considered as group B. The serum level of TPO-Ab was estimated. The study revealed significantly higher (p<0.001) levels of TPO-Ab (463.80±532.55 U/mL, median 122.9) of group A in comparison to group B (184.1±375.1 U/mL, median 40.8). TPO-Ab levels were significantly (p <0.001) more positive in group A 38/60(63.3%) compared with group B 14/60(23.3.%). TPO-Ab were positively correlated (r-+0.168) with the severity of the acne vulgaris but was not statistically significant (p-0.200).