Photoredox/Nickel‐Catalyzed Cross‐Coupling of Alkynyl Bromides and <i>α</i>‐Silylamines for the Synthesis of Propynylamines

Abstract Propynylamines are prevalent structures widely existing in biologically active compounds and natural products. In this study, we present a novel alkynylation approach for synthesizing propargylamines by cross‐coupling of alkynyl bromides and α ‐silylamines via a nickel metallaphotoredox catalysis. A diverse range of N ‐heterocyclic and acyclic α ‐silylamines, along with aromatic and aliphatic alkynyl bromides, are nicely incorporated, delivering structurally diverse propargylamines in moderate to good yields. Mechanistic studies suggest that the reaction proceeds through a radical pathway.