Automated Insulin Delivery in Elderly with Type 1 Diabetes: A Prespecified Analysis of the Extension Phase
The Automated Insulin Delivery in Elderly with Type 1 Diabetes (AIDE T1D) trial randomized 82 adults ≥65 years with type 1 diabetes (T1D) to hybrid closed loop (HCL), predictive low glucose suspend (PLGS), and sensor-augmented pump (SAP) therapy in a randomized crossover trial. Seventy-five of the 78 completers joined an extension phase in which they were offered the pump mode of their choice for an additional 3 months. Mean age was 71 ± 4 years (range 65-86 years) and mean duration of T1D was 42 ± 17 years (range 1-68 years). Use of HCL was selected by 91%, PLGS by 8%, and continuous glucose monitoring with injections by 1%. For participants selecting HCL, time-in-range 70-180 mg/dL was similar in the randomized controlled trial and extension phase (mean 75% ± 10%). One severe hypoglycemic event was reported. HCL was preferred over PLGS or SAP and remained effective in older adults with T1D. Clinical Trial Registration: NCT04016662.
Authors
- Kellee M. Miller (ORCID: https://orcid.org/0000-0002-5684-8284)
- Kamille Janess (ORCID: https://orcid.org/0000-0001-5771-4133)
- Anna Casu (ORCID: https://orcid.org/0000-0001-6924-0617)
- Naomi Chaytor (ORCID: https://orcid.org/0000-0001-8821-289X)
- Donna Desjardins
- Lauren Kanapka (ORCID: https://orcid.org/0000-0003-4440-5168)
- Shafaq Rizvi (ORCID: https://orcid.org/0000-0002-2607-4812)
- Richard E. Pratley (ORCID: https://orcid.org/0000-0002-2912-1389)
- Yogish C. Kudva (ORCID: https://orcid.org/0000-0003-0285-6622)
- Robert J. Henderson (ORCID: https://orcid.org/0000-0001-6805-269X)
- Vishwanath Pattan (ORCID: https://orcid.org/0000-0002-7077-8331)
- Amy J. Peleckis (ORCID: https://orcid.org/0000-0002-3772-2782)
- Ruth S. Weinstock (ORCID: https://orcid.org/0000-0001-5859-5666)
- Roy W. Beck (ORCID: https://orcid.org/0000-0002-5194-8446)
- Michael Roehrhoff Rickels (ORCID: https://orcid.org/0000-0002-9253-838X)
- Suzan Bzdick
- Keri Whitaker
- JORGE L. JO KAMIMOTO
- Craig Kollman
Institutions
- Mayo Clinic (US)
- Washington State University Spokane (US)
- SUNY Upstate Medical University (US)
- T1D Exchange (US)
- Science Exchange (United States) (US)
- Mayo Clinic in Arizona (US)
- Translational Research Institute for Metabolism and Diabetes (US)
- Elkhart Clinic (US)
- Jaeb Center for Health Research (US)
- Mayo Clinic in Florida (US)
- Mishawaka-Penn-Harris Public Library (US)
- University of Pennsylvania (US)
- Georgia Highlands College (US)
Publication Details
- Journal
- Diabetes Technology & Therapeutics
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1089/dia.2024.0560
- Citations
- 4
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 5.18