Decreased brain interstitial fluid dynamics is associated with risk of Alzheimer’s disease-related cognitive decline
The SVM model based on diffusivities and ALPS was effective for AD dementia diagnosis, and higher ALPS levels are associated with a lower risk of AD-related changes. These findings suggest that ALPS may provide a useful AD progression or treatment biomarker.
Authors
- Huijuan Chen (ORCID: https://orcid.org/0000-0002-5765-4422)
- Juan Helen Zhou (ORCID: https://orcid.org/0000-0002-0180-8648)
- Liangdong Zhou (ORCID: https://orcid.org/0000-0002-8389-274X)
- Yihao Guo (ORCID: https://orcid.org/0000-0002-3294-4351)
- Weiyuan Huang (ORCID: https://orcid.org/0000-0002-8062-0255)
- Tao Liu (ORCID: https://orcid.org/0000-0001-5347-5892)
- Kun Zhang (ORCID: https://orcid.org/0000-0003-3475-7127)
- Feng Chen (ORCID: https://orcid.org/0000-0002-9129-7895)
- Xiaoyi Wang
- Yi Wang (ORCID: https://orcid.org/0000-0001-9081-120X)
Institutions
- National University of Singapore (SG)
- Cornell University (US)
- MIND Research Institute (US)
- Hainan General Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111295
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55