The Utility of Myeloperoxidase Immunostaining to Characterize Immune Deposits in Patients With Crescentic Glomerulonephritis
Our study demonstrated that glomerular immune deposits in patients with crescentic GN with positive MPO serology demonstrated MPO positivity in the pattern of immune deposits in the majority of cases. Glomerular immune complexes in patients with MPO-positive crescentic GN therefore represent MPO-IgG immune complexes and should be thought of as one disease rather than a second disease process.
Authors
- Alejandro Best-Rocha
- Rachelle Gietzen (ORCID: https://orcid.org/0000-0002-9213-1803)
- Christopher P. Larsen (ORCID: https://orcid.org/0000-0002-7175-0242)
- Tiffany Caza
Institutions
- Arkana Laboratories (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.ekir.2025.03.001
- Citations
- 4
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases