[Translated article] Multicenter, Prospective, Case–Control Study of Exposome in Melanoma
UV radiation is the main etiological agent of skin cancer. Other factors such as pollution, diet and lifestyle are also contributing factors. Our aim was to investigate the association between melanoma and exposome factors in the Spanish population with a prospective multicenter case-control study. Case group included patients with melanoma while the control group included people who attended the consultations as companions without a past medical history of skin cancer. A total of 73 melanoma patients and 126 controls were included. The former group included more outdoor workers, a history of skin cancer, drug use (acetylsalicylic acid, antidepressants and ACE inhibitors, p<0.05), more sun exposure (p<0.001) and more sunburns (p=0.04). Controls used shade (p=0.04) or clothing (p<0.001) and the sun protection factor (SPF) used 15 years earlier was higher (p=0.04). Melanoma-related exposome factors are associated with sun exposure, drug intake and food. Prevention strategies should target specific populations, such as outdoor workers by promoting sun-safe behaviors and healthy lifestyle habits since childhood.
Authors
- Oriol Yélamos (ORCID: https://orcid.org/0000-0002-8058-3095)
- Manuel Almenara‐Blasco (ORCID: https://orcid.org/0000-0002-4350-401X)
- Carlos González‐Cruz (ORCID: https://orcid.org/0000-0003-0117-8858)
- Isabel Abadías‐Granado (ORCID: https://orcid.org/0000-0002-5301-1059)
- José Bañuls (ORCID: https://orcid.org/0000-0002-0990-7608)
- M. Almagro
- Trinidad Montero‐Vílchez (ORCID: https://orcid.org/0000-0003-4035-7955)
- Yolanda Gilaberte (ORCID: https://orcid.org/0000-0001-8034-3617)
- Sonia de-la-Fuente-Meira
- Alba Navarro‐Bielsa (ORCID: https://orcid.org/0000-0003-1171-6007)
- Victoria Fuentelsaz
- Ángeles Flórez (ORCID: https://orcid.org/0000-0001-9373-7826)
- A. Diago (ORCID: https://orcid.org/0000-0003-2209-248X)
- A. Buendía‐Eisman
- P Gil-Pallares
- M. Colmenero (ORCID: https://orcid.org/0000-0003-3387-6271)
- Tamara Gracia‐Cazaña (ORCID: https://orcid.org/0000-0002-0523-2076)
- S. Arias-Santiago
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universidad de Granada (ES)
- Hospital de Sant Pau (ES)
- Hospital Costa del Sol (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Centro de Salud Casa del Barco (ES)
- Hospital Royo Villanova (ES)
- Hospital Universitario Miguel Servet (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Clínico Universitario Lozano Blesa (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Complejo Hospitalario de Pontevedra (ES)
Publication Details
- Journal
- Actas Dermo-Sifiliográficas
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.ad.2025.03.008
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00