Precise subcellular organelle-targeted analyses of hepatotoxicity of Polygonum multiflorum
Collectively, our findings revealed the organelle heterogeneity of PMR-induced hepatotoxicity and identified quercetin as a potential toxic component in PMR. This study provides a novel conjunct strategy to screen and discover potential toxic components and shapes the understanding of toxicity warning and clinically safe use of herbal medicines such as PMR.
Authors
- Zhi Ma (ORCID: https://orcid.org/0000-0002-5803-4954)
- Jianzhi Wu
- Rong Sun (ORCID: https://orcid.org/0000-0002-0950-1480)
- Yijie Li (ORCID: https://orcid.org/0009-0004-3636-9624)
- Runping Liu (ORCID: https://orcid.org/0000-0001-8873-5252)
- Yinhao Zhang
- Xiaojiaoyang Li (ORCID: https://orcid.org/0000-0003-0291-5856)
- Shuni Duan
Institutions
- Beijing University of Chinese Medicine (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Chinese Herbal Medicines
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.chmed.2025.03.001
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00