1,2-Acylphosphinylation of Styrenes to Access β-Aryl-γ-ketophosphine Oxides by Irradiation-Induced Radical Relay
An acylphosphinylation reaction has been devised for the synthesis of β-aryl-γ-ketophosphine oxides, employing styrenes and acyl azolium salts through an irradiation-induced radical relay mechanism. This method effectively constructs C-C and C-P bonds while demonstrating excellent functional group tolerance. Mechanistic studies revealed that a radical-addition-coupling-elimination cascade process was involved in this reaction.
Authors
- Shihao Li
- Shilu Fan (ORCID: https://orcid.org/0000-0003-0315-7874)
- Ming‐Chen Fu (ORCID: https://orcid.org/0000-0001-7617-7521)
- Yandong Dou
- Lishuai Lu
- Dengyu Yin (ORCID: https://orcid.org/0000-0003-0502-7053)
- Yanwu Zhu
Institutions
- Hefei University of Technology (CN)
- Catalytic Materials (United States) (US)
- Buchang Pharma (China) (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1021/acs.joc.4c02749
- Citations
- 4
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- Fundamental Research Funds for the Central Universities