Effect of glioblastoma and brain radiotherapy on T-lymphocyte subpopulations in rodents

These findings confirm that the presence of glioblastoma and brain-irradiation affect T-lymphocyte subpopulations in mice. The inclusion of lymph nodes in the irradiated area led to a long-term decrease in naïve CD8<sup>+</sup>-lymphocytes. Further mechanistic studies are needed to understand the molecular basis of radiation impact on T-lymphocyte subpopulations.

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Publication Details

Journal
Radiotherapy and Oncology
Published
2025-03-11
DOI
https://doi.org/10.1016/j.radonc.2025.110801
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Effect of glioblastoma and brain radiotherapy on T-lymphocyte subpopulations in rodents

Thao-Nguyen Pham, Juliette Thariat, Serge M. Candéias, Julie Coupey et al.
Radiotherapy and Oncology
Neuroinflammation and Neurodegeneration Mechanisms
article

Effect of glioblastoma and brain radiotherapy on T-lymphocyte subpopulations in rodents

Thao-Nguyen Pham, Juliette Thariat, Serge M. Candéias, Julie Coupey, Samuel Valable, Florian Yger
article en

Abstract

These findings confirm that the presence of glioblastoma and brain-irradiation affect T-lymphocyte subpopulations in mice. The inclusion of lymph nodes in the irradiated area led to a long-term decrease in naïve CD8<sup>+</sup>-lymphocytes. Further mechanistic studies are needed to understand the molecular basis of radiation impact on T-lymphocyte subpopulations.

Radiotherapy and OncologyVol. 206
Centre National de la Recherche Scientifique (FR), Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR), CEA Grenoble (FR), Institut de Recherche Interdisciplinaire de Grenoble (FR), Normandie Université (FR), Laboratoire de Physique Corpusculaire de Caen (FR), Laboratoire de Chimie et Biologie des Métaux (FR), Cyceron (FR), Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux (FR), Université Paris Dauphine-PSL (FR), Université Grenoble Alpes (FR), Université de Caen Normandie (FR)
Agence Nationale de la Recherche, Ligue Contre le Cancer, Centre National de la Recherche Scientifique, LabEx PRIMES, CHIST-ERA
Zero hunger
Openalex Percentile: Top 94%
Neuroinflammation and Neurodegeneration Mechanisms
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