Combined metabolomics and network pharmacology to elucidate the mechanisms of Huiyang Shengji decoction in treating diabetic skin ulcer mice
The findings suggested that HYSJD regulates biotin metabolism by reducing excess levels of linoleic and deoxycholic acids and increasing levels of L-lysine, which in turn promotes diabetic wound healing by promoting M2 macrophage polarization through PPARγ up-regulation. These findings indicated that HYSJD is a decoction that can effectively treat diabetic skin ulcers.
Authors
- Haoyue Zhu (ORCID: https://orcid.org/0009-0008-6609-398X)
- Yazhuo Wang (ORCID: https://orcid.org/0000-0003-3952-9553)
- Huike Ma
- Zhengchun Wang
- Danyang Yang
- Ning Zhao (ORCID: https://orcid.org/0000-0001-7702-7605)
- Xiang Zhang (ORCID: https://orcid.org/0000-0002-6416-558X)
- Jia Chen (ORCID: https://orcid.org/0000-0001-6415-7718)
- Ping Li (ORCID: https://orcid.org/0000-0002-4926-3835)
- Li Zhou (ORCID: https://orcid.org/0000-0002-2815-9430)
- Xiujuan He (ORCID: https://orcid.org/0000-0002-0689-248X)
- Li Zhao (ORCID: https://orcid.org/0009-0009-8940-8873)
- Baoquan Qu
Institutions
- Capital Medical University (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.phymed.2025.156569
- Citations
- 4
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China