Activation of Neutrophil Extracellular Trap Formation in Patients with Heart Failure and a Preserved Ejection Fraction
Transcriptomics analyses suggest activation of neutrophil extracellular trap formation pathways in patients with HFpEF. This pathway is associated with endothelial and coronary microvascular dysfunction and might be a target for future drug development in patients with HFpEF.
Authors
- Mintu Nath (ORCID: https://orcid.org/0000-0002-0753-0464)
- Mark M. Iles (ORCID: https://orcid.org/0000-0002-2603-6509)
- Tristan V. de Jong
- Lukas Baumhove (ORCID: https://orcid.org/0000-0002-5860-7943)
- Karin Conde‐Knape
- Wouter Ouwerkerk (ORCID: https://orcid.org/0000-0002-2000-9358)
- Natasha Barascuk Michaelsen
- Andreas B. Gevaert (ORCID: https://orcid.org/0000-0002-1338-4133)
- Bart J. van Essen (ORCID: https://orcid.org/0000-0002-9057-7449)
- Chim C. Lang (ORCID: https://orcid.org/0000-0002-4530-3078)
- Jasper Tromp (ORCID: https://orcid.org/0000-0001-6043-0713)
- Andrea Koekemoer
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Djordje Djordjevic (ORCID: https://orcid.org/0000-0003-3669-6292)
- Ganash N Tharshana
Institutions
- University Medical Center Groningen (NL)
- University of Antwerp (BE)
- National University of Singapore (SG)
- University of Groningen (NL)
- University of Dundee (GB)
- Novo Nordisk (Denmark) (DK)
- Glenfield Hospital (GB)
- Ninewells Hospital (GB)
- Antwerp University Hospital (BE)
- National University Heart Centre Singapore (SG)
- NIHR Leicester Cardiovascular Biomedical Research Unit (GB)
- National University Health System (SG)
- Institute of Infection and Immunity (CA)
- NIHR Leicester Biomedical Research Centre (GB)
Publication Details
- Journal
- Journal of Cardiac Failure
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.cardfail.2025.02.015
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Dutch Cardiovascular Alliance
- European Commission
- Hartstichting
- Novo Nordisk