Activation of Neutrophil Extracellular Trap Formation in Patients with Heart Failure and a Preserved Ejection Fraction

Transcriptomics analyses suggest activation of neutrophil extracellular trap formation pathways in patients with HFpEF. This pathway is associated with endothelial and coronary microvascular dysfunction and might be a target for future drug development in patients with HFpEF.

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Publication Details

Journal
Journal of Cardiac Failure
Published
2025-03-11
DOI
https://doi.org/10.1016/j.cardfail.2025.02.015
Citations
1
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
1.39

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article

Activation of Neutrophil Extracellular Trap Formation in Patients with Heart Failure and a Preserved Ejection Fraction

Mintu Nath, Mark M. Iles, Tristan V. de Jong, Lukas Baumhove et al.
1 citations
Journal of Cardiac Failure
Cardiovascular Function and Risk Factors
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Activation of Neutrophil Extracellular Trap Formation in Patients with Heart Failure and a Preserved Ejection Fraction

Mintu Nath, Mark M. Iles, Tristan V. de Jong, Lukas Baumhove, Karin Conde‐Knape, Wouter Ouwerkerk, Natasha Barascuk Michaelsen, Andreas B. Gevaert, Bart J. van Essen, Chim C. Lang, Jasper Tromp, Andrea Koekemoer, Adriaan A. Voors, Djordje Djordjevic, Ganash N Tharshana
article en
1 citations

Abstract

Transcriptomics analyses suggest activation of neutrophil extracellular trap formation pathways in patients with HFpEF. This pathway is associated with endothelial and coronary microvascular dysfunction and might be a target for future drug development in patients with HFpEF.

Journal of Cardiac FailureVol. 32(3)
University Medical Center Groningen (NL), University of Antwerp (BE), National University of Singapore (SG), University of Groningen (NL), University of Dundee (GB), Novo Nordisk (Denmark) (DK), Glenfield Hospital (GB), Ninewells Hospital (GB), Antwerp University Hospital (BE), National University Heart Centre Singapore (SG), NIHR Leicester Cardiovascular Biomedical Research Unit (GB), National University Health System (SG), Institute of Infection and Immunity (CA), NIHR Leicester Biomedical Research Centre (GB)
Dutch Cardiovascular Alliance, European Commission, Hartstichting, Novo Nordisk
Good health and well-being
Openalex Percentile: Top 22%
Cardiovascular Function and Risk Factors
1.39
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