Topical Losartan Treatment of Herpes Simplex Virus- or Varicella-Zoster Virus-Induced Corneal Scarring: A Case Series
Topical losartan, a known inhibitor of fibrotic TGF-beta signaling, is potentially an effective alternative in the treatment of stromal scarring fibrosis caused by corneal HSV and VZV infections. Patients with HSV- or VZV keratitis-induced corneal scarring may be ideal candidates for planned clinical trials of the efficacy and safety of topical losartan treatment.
Authors
- Laura E. Drew-Bear (ORCID: https://orcid.org/0000-0002-9067-9154)
- Barbara A L Dutra (ORCID: https://orcid.org/0000-0003-4813-713X)
- Steven E. Wilson (ORCID: https://orcid.org/0000-0001-8121-960X)
- Marcony R. Santhiago (ORCID: https://orcid.org/0000-0001-7523-1565)
- Rodrigo Carlos de Oliveira (ORCID: https://orcid.org/0000-0002-6851-5778)
- Lycia Pedral Sampaio (ORCID: https://orcid.org/0000-0003-4640-6527)
- Danielle Arroyo
- Samantha Herretes
Institutions
- Cleveland Clinic (US)
- Universidade de São Paulo (BR)
- Cleveland Eye Clinic (US)
Publication Details
- Journal
- Case Reports in Ophthalmology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1159/000545215
- Citations
- 3
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 5.64