Exosome-Derived miR-148a-3p Protect against Tumor Proliferation and Metastasis of Esophageal Squamous Carcinoma
Above experimental results explained that miR-148a-3p showed significant tumor inhibition function both in serum exosomes of ESCC patients and in functional tests of cancer cell lines in vitro, suggesting that exosome miR-148a-3p can inhibit tumor progression and has the potential to be used as an indicator of clinical ESCC diagnosis and prognosis.
Authors
- Hiroki Morishita
- Koichi Hayano (ORCID: https://orcid.org/0000-0003-4733-8220)
- Toshiaki Makino (ORCID: https://orcid.org/0000-0002-2524-8745)
- Masaya Uesato (ORCID: https://orcid.org/0000-0002-6766-5600)
- Yuri Nishioka
- Shinichiro Iida (ORCID: https://orcid.org/0009-0001-6454-9372)
- Yasunori Matsumoto (ORCID: https://orcid.org/0000-0002-6239-6691)
- Tadashi Shiraishi (ORCID: https://orcid.org/0000-0003-1424-3049)
- Nobuhumi Sekino
- Hisahiro Matsubara (ORCID: https://orcid.org/0000-0002-2335-4704)
- Akira Nakano (ORCID: https://orcid.org/0000-0002-2506-1825)
- Ryota Otsuka (ORCID: https://orcid.org/0000-0001-7360-9069)
- Masayuki Kano (ORCID: https://orcid.org/0000-0002-1797-5176)
- Koichiro Okada (ORCID: https://orcid.org/0000-0001-6443-3882)
- Jingting Zhang
- Toshiki Kamata
- Masaya Yamada
- Takeshi Toyozum
Institutions
- Chiba University (JP)
Publication Details
- Journal
- Oncology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1159/000544987
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00