Significance of the Monocyte CCR2-CCL2 Axis in Triple-negative Breast Cancer
Our study demonstrated the activation of the monocyte CCR2-CCL2 axis in TNBC for the first time. This activation occurs mainly in patients who do not respond to NAC. Circulating CCL2 levels ≤89.61 pg/mL were found to predict, to some extent, the achievement of pCR in patients with TNBC receiving NAC.
Authors
- Alicja Bukowska (ORCID: https://orcid.org/0000-0002-3849-7724)
- Witold Kycler (ORCID: https://orcid.org/0000-0001-7994-0756)
- Joanna Załuska-Kusz
- Magdalena Budzyń (ORCID: https://orcid.org/0000-0003-2296-3599)
- Joanna Grupińska (ORCID: https://orcid.org/0000-0002-1814-1771)
- Elżbieta Kaja (ORCID: https://orcid.org/0000-0003-1277-6140)
- J Brzeziński
- Agata Kubicka (ORCID: https://orcid.org/0009-0003-4108-8328)
- Marcelina Sperling (ORCID: https://orcid.org/0000-0002-0919-9453)
Institutions
- Poznan University of Medical Sciences (PL)
- Greater Poland Cancer Center (PL)
Publication Details
- Journal
- Archives of Medical Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.arcmed.2025.103205
- Citations
- 3
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Narodowe Centrum Nauki