Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer
We describe a potential link in HPV+ OPSCCs between reduced DNA damage and other tumor-intrinsic and immune-related contributors to recurrence risk, opening opportunities to detect and target this high-risk biology.
Authors
- Lova Sun (ORCID: https://orcid.org/0000-0002-5015-2964)
- Jalal B. Jalaly (ORCID: https://orcid.org/0000-0001-6978-0242)
- John N. Lukens (ORCID: https://orcid.org/0000-0001-7104-413X)
- Travis P. Schrank (ORCID: https://orcid.org/0000-0002-8297-3329)
- Phyllis A. Gimotty (ORCID: https://orcid.org/0000-0002-3850-9799)
- Devraj Basu (ORCID: https://orcid.org/0000-0003-0452-1033)
- Joseph A. Califano (ORCID: https://orcid.org/0000-0002-4715-6761)
- Malay K. Sannigrahi (ORCID: https://orcid.org/0000-0002-0377-5771)
- Alexander Lin (ORCID: https://orcid.org/0000-0001-8236-880X)
- Alexander T. Pearson (ORCID: https://orcid.org/0000-0003-2801-7456)
- Iain M. Morgan (ORCID: https://orcid.org/0000-0002-4949-3032)
- Ahmed Diab (ORCID: https://orcid.org/0000-0001-6626-7013)
- Lovely Raghav
- David Q. Rich (ORCID: https://orcid.org/0000-0001-7132-0069)
- Sambit Kumar Mishra (ORCID: https://orcid.org/0000-0001-8319-0599)
- Karen Brown (ORCID: https://orcid.org/0000-0002-5217-1501)
- Robert M. Brody (ORCID: https://orcid.org/0000-0001-6639-8830)
- David Shimunov
- Xinyi Liu (ORCID: https://orcid.org/0000-0001-5983-2766)
- Jianxin You (ORCID: https://orcid.org/0000-0001-8962-8491)
- Roger B. Cohen
Institutions
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- University of San Diego (US)
- Virginia Commonwealth University (US)
- Hospital of the University of Pennsylvania (US)
- University of California San Diego (US)
- University of Illinois Chicago (US)
- University of Chicago Medical Center (US)
- Stony Brook Medicine (US)
- National Cancer Institute (US)
- Department of Health and Human Services (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1093/jnci/djaf053
- Citations
- 2
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- American Society of Clinical Oncology
- University of Pennsylvania
- National Institutes of Health
- National Cancer Institute