Enhancing insight into regional differences: hierarchical linear models in multiregional clinical trials
We offer a comprehensive framework for understanding and addressing regional differences in the primary endpoint for MRCTs. Through the proposed strategies with figures and required sample size considering the budget constraints, designs for MRCT could be more efficient.
Authors
- Seung‐Ho Kang (ORCID: https://orcid.org/0000-0002-7593-7899)
- Jeewuan Kim (ORCID: https://orcid.org/0000-0002-2945-3893)
Institutions
- Yonsei University (KR)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12874-025-02479-4
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea