Characterization of FosA13, a novel fosfomycin glutathione transferase identified in a Morganella morganii isolate from poultry
A novel chromosomal fosfomycin resistance gene, <i>fosA13</i>, was identified in an animal <i>M. morganii</i> isolate, and its enzymatic parameters were characterized. This protein shares the highest aa identity of 55.6% with the functionally characterized protein FosA and has all the essential functional residues of FosA proteins. Exploring more antimicrobial resistance mechanisms of this pathogen would help clinicians choose effective drugs to treat infectious diseases in animal husbandry and clinical practice and facilitate the development of methods to prevent the spread of resistance between bacteria of different species.
Authors
- Rey‐Heng Hu (ORCID: https://orcid.org/0000-0001-6709-031X)
- Lulu Huang
- Da‐Wei Huang (ORCID: https://orcid.org/0000-0003-4355-7047)
- Yunliang Hu (ORCID: https://orcid.org/0000-0003-4004-537X)
- Susu Chen (ORCID: https://orcid.org/0000-0002-5065-1157)
- Chunhan Song
- Pengfei Jiang (ORCID: https://orcid.org/0000-0001-8996-2406)
- Runzhi Zhang (ORCID: https://orcid.org/0000-0001-9001-0154)
- Xiuxiu Wang (ORCID: https://orcid.org/0009-0008-6576-4200)
- Yan Yu (ORCID: https://orcid.org/0000-0001-6496-5045)
- Qiyu Bao
- Junwan Lu (ORCID: https://orcid.org/0000-0002-7378-6783)
- Wei Pan (ORCID: https://orcid.org/0000-0001-8733-0683)
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Jinhua University of Vocational Technology (CN)
- Yuxian People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3389/fcimb.2025.1534084
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59