PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation
PKN2 expression was increased in PMN-MDSCs derived from human and mouse EC tissues. PKN2 plays a role in enhancing the immunosuppressive activity of PMN-MDSCs by facilitating STAT3 phosphorylation and CPT1B transcription, which in turn leads to increased CPT1B-mediated FAO in PMN-MDSCs. Targeted inhibition of PKN2 is expected to improve immunotherapeutic efficacy in EC patients.
Authors
- Guanghui Cui (ORCID: https://orcid.org/0000-0002-1260-7198)
- Zhichao Hou (ORCID: https://orcid.org/0000-0002-3989-2654)
- Tingting Fu (ORCID: https://orcid.org/0000-0003-3902-9049)
- Guoqing Zhang (ORCID: https://orcid.org/0000-0001-8827-7546)
- Xiao Fu (ORCID: https://orcid.org/0000-0001-5279-9377)
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s10020-025-01132-6
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59