AgNO₃‐Catalyzed Regio‐selective Bis‐heteroannulation of <i>o</i>‐Hydroxyphenyl Enaminones and Yne‐enones: A Facile synthesis of Functionalized 3‐(Furan‐3‐ylmethyl) Chromones

Abstract An efficient AgNO 3 ‐catalyzed regio‐selective bis‐heteroannulation of o ‐hydroxyphenyl enaminones with yne‐enones for the synthesis of highly functionalized 3‐(furan‐3‐ylmethyl) chromones has been developed. The protocol enables the simultaneous construction of chromone and furan skeleton in one‐step cascade reaction. Furthermore, high easily accessible starting materials, regioselectivity, room temperature, good to excellent yields, broad substituent tolerance, further gram‐scale synthesis and derivatization make this strategy potential synthetic application value in synthetic and medicinal chemistry.