Rh(III)‐Catalyzed Regioselective [3+2]‐Annulation of Indoles with 1,3‐Enynes to Access 3<i>H</i>‐pyrrolo[1,2‐<i>a</i>]indol‐3‐ones
Abstract Herein, we present a novel and highly efficient strategy for the synthesis of synthetically valuable 3 H ‐pyrrolo[1,2‐ a ]indol‐3‐ones via a Rh(III)‐catalyzed regioselective [3+2] annulation strategy. The protocol ensures precise regioselective insertion of substituted 1,3‐enynes at the less sterically hindered site, while offering a broad substrate scope, excellent functional group compatibility, and mild reaction conditions. Moreover, the methodology is amenable to gram‐scale synthesis and demonstrates the successful application of terbinafine as a substrate within this transformation.
Authors
- Togati Naveen (ORCID: https://orcid.org/0000-0003-3424-4348)
- Bhargav Desai (ORCID: https://orcid.org/0000-0002-3564-6181)
- Pradeep Girase
- Sanjeev Kumar (ORCID: https://orcid.org/0000-0002-9093-0185)
- Vinaykumar Kanchupalli (ORCID: https://orcid.org/0000-0002-2298-4376)
- Sanjeev Jadhav (ORCID: https://orcid.org/0000-0001-9911-5569)
Institutions
- University of Hyderabad (IN)
- Sardar Vallabhbhai National Institute of Technology Surat (IN)
- National Institute of Pharmaceutical Education and Research - Ahmedabad (IN)
- National Institute of Pharmaceutical Education and Research (IN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1002/ajoc.202400810
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00