Epidural analgesia during esophagectomy and esophageal cancer prognosis: A population‐based nationwide study in Finland
This large esophagectomy (cancer) cohort in Finland was used to compare those who received epidural analgesia with those who did not for associations with late mortality in a retrospective analysis and where anesthesia and analgesia treatments were not controlled. The findings showed that when other recognized risks for mortality were taken into account, there was not a meaningful difference in relative risk for late mortality related to the presence or absence of epidural analgesia, though the analgesia treatments were not randomly allocated. These results do not rule out associations of analgesia choice with other outcomes that might be important to patients.
Authors
- Juha Saarnio (ORCID: https://orcid.org/0000-0002-8443-3625)
- Olli Helminen (ORCID: https://orcid.org/0000-0001-9544-6475)
- Mika Helmiö
- Joonas H. Kauppila (ORCID: https://orcid.org/0000-0001-6740-3726)
- Eero Sihvo (ORCID: https://orcid.org/0000-0002-2694-8487)
- Antti Valtola (ORCID: https://orcid.org/0000-0001-5923-968X)
- Sanna Meriläinen (ORCID: https://orcid.org/0000-0002-0789-9042)
- Jari Räsänen (ORCID: https://orcid.org/0000-0002-7826-532X)
- Elina Lietzén (ORCID: https://orcid.org/0000-0002-7514-7176)
- Tuula Tyrväinen
- Vesa Koivukangas (ORCID: https://orcid.org/0000-0002-2966-0286)
- Ari Ristimäki (ORCID: https://orcid.org/0000-0002-5373-9234)
- Raija Kallio (ORCID: https://orcid.org/0000-0002-5912-496X)
- Vesa‐Matti Pohjanen (ORCID: https://orcid.org/0000-0002-4129-4346)
- Arto Kokkola (ORCID: https://orcid.org/0000-0002-8286-0666)
- Heikki Huhta (ORCID: https://orcid.org/0000-0002-6273-198X)
- Taina Rantanen (ORCID: https://orcid.org/0000-0002-1604-1945)
- Vesa Toikkanen
- Simo Laine
- Pia H. Petäjäkangas (ORCID: https://orcid.org/0009-0003-2698-3690)
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- University of Eastern Finland (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Karolinska Institutet (SE)
- Kuopio University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Central Finland Health Care District (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Acta Anaesthesiologica Scandinavica
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1111/aas.70016
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Finnish Cancer Institute
- Päivikki ja Sakari Sohlbergin Säätiö
- Sigrid Juséliuksen Säätiö
- Orionin Tutkimussäätiö