Palladium‐Catalyzed Three‐Component Reaction of Enol Ethers, Salicylaldehyde, and Trimethyl Orthoformate: A Fast Synthesis of Tetrahydro‐<scp>2H</scp>,<scp>5H</scp>‐Pyrano[2,3‐b]Chromenes
ABSTRACT The Pd‐catalyzed three‐component reaction of enol ethers, methyl orthoformate, and salicylaldehyde is described. Both steroid and non‐steroid enol ethers are compatible. This reaction allows the construction of tetrahydro‐2H,5H‐pyrano[2,3‐b]chromene. Unambiguous NMR characterization and X‐ray diffraction structures are provided.
Authors
- Martín A. Iglesias‐Arteaga (ORCID: https://orcid.org/0000-0003-4764-7664)
- Marcos Flores-Ãlamo (ORCID: https://orcid.org/0000-0002-2996-7616)
- William H. García‐Santos (ORCID: https://orcid.org/0000-0002-6981-2424)
- José A. Olivares‐Castillo
- Melina D. Cordova‐Rodríguez
Institutions
- Universidad Autónoma de la Ciudad de México (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Journal of Heterocyclic Chemistry
- Published
- 2025-03-02
- DOI
- https://doi.org/10.1002/jhet.4949
- Citations
- 1
- Primary Topic
- Synthesis of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.39