Temporomandibular joint degeneration arises spontaneously in STR/ort mice and is prevented by targeted aggrecanase inhibition
Using our new mouse TMJ-OA scoring system we have found that OA affects joints other than the knee in the STR/Ort strain. Genetic gain-of-function modification of STR/Ort mice with an aggrecanase-selective mutant of tissue inhibitor of metalloproteinase (TIMP)-3 also affords in vivo chondroprotection against this TMJ-OA.
Authors
- Kazuhiro Ooi (ORCID: https://orcid.org/0000-0002-1678-0158)
- Behzâd Javaheri (ORCID: https://orcid.org/0000-0001-7941-3104)
- Andrew A. Pitsillides (ORCID: https://orcid.org/0000-0002-3861-998X)
- Shuichi Kawashiri
- Kazuhiro Yamamoto (ORCID: https://orcid.org/0000-0002-8481-775X)
- Yutaka Kobayashi
- Ioannis Kanakis (ORCID: https://orcid.org/0000-0001-6410-1482)
- Takao Sakai (ORCID: https://orcid.org/0000-0002-7375-5450)
- Anders Jensen
- George Bou–Gharios (ORCID: https://orcid.org/0000-0002-9563-9418)
- Hiroyuki Nakamura (ORCID: https://orcid.org/0000-0002-2524-3063)
- Fadi Jarad
Institutions
- Royal Veterinary College (GB)
- University of Chester (GB)
- Fujita Health University (JP)
- University of Liverpool (GB)
- Kanazawa Medical University (JP)
- University of the Ryukyus (JP)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100599
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34