The clinical characteristics of 10 cases and adult height of six cases of rare familial male-limited precocious puberty
The most prevalent genotype among FMPP patients in this study was the <i>LHCGR M398T</i> mutation. Early intervention using a regimen including letrozole and spironolactone, and later GnRHa, appears beneficial in limiting physical signs and improving adult height without major side effects. However, the longer-term effects on fertility require further investigation.
Authors
- Qiuli Chen (ORCID: https://orcid.org/0000-0001-8531-6175)
- Song Guo
- Rujiang Zheng
- Yanhong Li (ORCID: https://orcid.org/0000-0002-0961-7870)
- Dongliang Xie
- Huamei Ma (ORCID: https://orcid.org/0000-0001-6057-5824)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-3067-2620)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Journal of Pediatric Endocrinology and Metabolism
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1515/jpem-2024-0602
- Primary Topic
- Sexual Differentiation and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00