Intestinal Depletion of TM6SF2 Exacerbates High-fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease through the Gut-liver Axis
TM6SF2 GKO aggravates liver lipid accumulation and liver injury in MASLD mice. TM6SF2 may play an important role in regulating intestinal flora and the progression of MASLD through the gut-liver axis.
Authors
- Congcong Min (ORCID: https://orcid.org/0000-0002-4752-7649)
- Yongning Xin (ORCID: https://orcid.org/0000-0002-3692-7655)
- Shuai Zhao (ORCID: https://orcid.org/0000-0002-1488-2601)
- Yurong Wang (ORCID: https://orcid.org/0000-0003-1137-1520)
- Zhenzhen Zhao (ORCID: https://orcid.org/0000-0002-5883-1056)
- Li-Zhen Chen
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-03-12
- DOI
- https://doi.org/10.14218/jcth.2024.00407
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00