Chlorogenic acid attenuates pyrrolizidine alkaloid-induced liver injury through modulation of the SIRT1/FXR signaling pathway
Our research suggests that Cga can serve as an effective treatment for PA-mediated hepatotoxicity. It appears that influencing the SIRT1/FXR signaling pathway might provide an innovative pharmacological approach to address liver damage caused by PAs.
Authors
- Jie Xu (ORCID: https://orcid.org/0000-0003-4049-0991)
- Lili Ding (ORCID: https://orcid.org/0000-0002-4831-3300)
- Aizhen Xiong (ORCID: https://orcid.org/0000-0002-6528-4652)
- Xing Yan
- Yang Li (ORCID: https://orcid.org/0000-0002-0677-3245)
- Qiao Xue (ORCID: https://orcid.org/0000-0001-5523-3918)
- Xunjiang Wang (ORCID: https://orcid.org/0009-0006-4973-3039)
- Deqing Ruan
- Yilin Chen (ORCID: https://orcid.org/0009-0000-9552-5990)
- Zhengtao Wang (ORCID: https://orcid.org/0000-0003-2797-4625)
- Yumeng Zhang (ORCID: https://orcid.org/0000-0002-4331-198X)
Institutions
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Seventh People's Hospital of Shanghai (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s13020-025-01077-2
- Citations
- 3
- Primary Topic
- Plant Toxicity and Pharmacological Properties
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China