Intense Uptake of 68Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases
A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68 Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.
Authors
- Qingqing Pan (ORCID: https://orcid.org/0000-0002-6983-2417)
- Silu Liu (ORCID: https://orcid.org/0000-0001-8477-8327)
- Yaping Luo (ORCID: https://orcid.org/0000-0002-5787-1136)
- Hongzhe Zhang (ORCID: https://orcid.org/0000-0003-3850-8611)
- Jie Feng (ORCID: https://orcid.org/0009-0008-6338-5178)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1097/rlu.0000000000005834
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00