A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway

The findings suggest that while SH2B1 variants are strongly associated with BMI, specific normal genotypes may independently contribute to OSA risk by increasing AHI values.

Authors

Mehmet Ali Karaselek (ORCID: https://orcid.org/0000-0003-3201-8945)
Şebnem Yosunkaya (ORCID: https://orcid.org/0000-0002-7859-8941)
Serkan Küççüktürk (ORCID: https://orcid.org/0000-0001-8445-666X)
Sennur Demirel
Hasibe Cıngıllı Vural (ORCID: https://orcid.org/0000-0003-2564-7807)

Institutions

Necmettin Erbakan University (TR)
Karamanoğlu Mehmetbey University (TR)

Publication Details

Journal: Expert Review of Endocrinology & Metabolism
Published: 2025-03-11
DOI: https://doi.org/10.1080/17446651.2025.2478068
Primary Topic: Regulation of Appetite and Obesity
Type: article
Field-Weighted Citation Impact: 0.00

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article

A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway

Mehmet Ali Karaselek, Şebnem Yosunkaya, Serkan Küççüktürk, Sennur Demirel et al.

Mar 11, 2025

Expert Review of Endocrinology & Metabolism

Regulation of Appetite and Obesity

article

A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway

Mehmet Ali Karaselek, Şebnem Yosunkaya, Serkan Küççüktürk, Sennur Demirel, Hasibe Cıngıllı Vural

March 11, 2025article en

Abstract

The findings suggest that while SH2B1 variants are strongly associated with BMI, specific normal genotypes may independently contribute to OSA risk by increasing AHI values.

Expert Review of Endocrinology & MetabolismVol. 20(3)

Necmettin Erbakan University (TR), Karamanoğlu Mehmetbey University (TR)

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Openalex Percentile: Top 95%

Regulation of Appetite and Obesity

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