Fruquintinib inhibits the migration and invasion of colorectal cancer cells by modulating epithelial-mesenchymal transition via TGF-β/Smad signaling pathway
These findings indicate that Fruquintinib effectively hampers the migration and invasion of CRC cells by disrupting the EMT process via the TGF-β/Smad signaling pathway. This study sheds light on the mechanisms by which fruquintinib inhibits CRC progression and underscores its potential for further clinical investigation.
Authors
- Qinqin Song (ORCID: https://orcid.org/0009-0000-8965-1069)
- Wanning Hu (ORCID: https://orcid.org/0009-0002-6958-3788)
- Hongjiao Wu (ORCID: https://orcid.org/0000-0002-0179-926X)
- Junzhi Hou
- Jiawei Liu (ORCID: https://orcid.org/0000-0003-1789-9430)
- Xuemei Zhang (ORCID: https://orcid.org/0000-0003-0705-4231)
- Zhi Zhang (ORCID: https://orcid.org/0000-0001-6530-9736)
- Ye Jin
- Guogui Sun
Institutions
- Hebei Medical University (CN)
- North China University of Science and Technology (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- North China University of Science and Technology Affiliated Hospital (CN)
- Tangshan Gongren Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3389/fonc.2025.1503133
- Citations
- 4
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.18