<i>Bacteroides fragilis</i> Toxin Suppresses METTL3-Mediated m6A Modification in Macrophage to Promote Inflammatory Bowel Disease
Our study reveals that BFT produced by ETBF leads to a reduction of m6A modifications by reducing METTL3 transcription and promotes ITGA5 expression in inflammatory macrophages. These findings provide new insights into the modulation of human m6A epitranscriptome in macrophages by gut microbiota and its significance in inflammatory bowel disease progression.
Authors
- Jing‐Yuan Fang (ORCID: https://orcid.org/0000-0003-2282-0248)
- Yilu Zhou (ORCID: https://orcid.org/0000-0002-4090-099X)
- Baoqin Xuan
- Nan Shen (ORCID: https://orcid.org/0000-0002-5875-4417)
- Muni Hu
- Jinmei Ding
- Xiaoqiang Zhu (ORCID: https://orcid.org/0000-0001-7486-0853)
- Yi Jiang (ORCID: https://orcid.org/0000-0002-0325-5282)
- Zhe Cui (ORCID: https://orcid.org/0000-0002-3345-5197)
- Zhijun Cao (ORCID: https://orcid.org/0000-0002-5519-9462)
- Lijun Ning (ORCID: https://orcid.org/0000-0001-7646-1784)
- Xiang Gao (ORCID: https://orcid.org/0000-0001-6397-5639)
- Weixun Li (ORCID: https://orcid.org/0000-0001-5644-4223)
- Yuqing Yan (ORCID: https://orcid.org/0009-0002-4436-0545)
- Li Tian (ORCID: https://orcid.org/0000-0003-3914-8240)
- Xiaoyan Wang (ORCID: https://orcid.org/0000-0002-7281-1078)
- Ying Zhao (ORCID: https://orcid.org/0000-0002-7927-4906)
- Yanru Ma
- Zhenyu Wang (ORCID: https://orcid.org/0000-0003-0807-7726)
- Xitao Xu (ORCID: https://orcid.org/0009-0005-8984-1264)
- Jie Hong (ORCID: https://orcid.org/0009-0005-9293-5114)
- Haoyan Chen (ORCID: https://orcid.org/0000-0001-7208-3181)
- Xiaowen Huang (ORCID: https://orcid.org/0000-0002-9637-0326)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-7786-0231)
Institutions
- Central South University (CN)
- Shandong University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Children's Medical Center (CN)
- Shanghai Cancer Institute (CN)
- Third Xiangya Hospital (CN)
- State Key Laboratory of Microbial Technology
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1093/ecco-jcc/jjae179
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China