Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways
IL-6/sIL-6R stimulation increased the extracellular secretion of cathepsin B and L precursors in HGFs, and these precursors became activated under acidic conditions. Cav-1 and ERK1/2 are involved in regulating the secretion of cathepsin B precursors.
Authors
- Yuki Shinoda-Ito (ORCID: https://orcid.org/0000-0001-9359-8977)
- Tomoko Yamaguchi-Tomikawa
- Shogo Takashiba (ORCID: https://orcid.org/0000-0002-4712-6829)
- Atsushi Ikeda (ORCID: https://orcid.org/0000-0002-1555-1986)
- Kazuhiro Omori (ORCID: https://orcid.org/0000-0002-4129-1401)
- Hiroya Kobayashi (ORCID: https://orcid.org/0000-0001-5222-8961)
- Ayaka Goto
- Kimito Hirai
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
Publication Details
- Journal
- Frontiers in Dental Medicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3389/fdmed.2025.1547222
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00