Single-cell and transcriptome analyses revealed CTHRC1 a potential therapeutic target mediating invasion and tumor microenvironment in TNBC: experimental validation
CTHRC1 was a molecule that exhibits characteristic expression in TNBC. CTHRC1 positive CAFs exert regulatory effects within the immunosuppressive microenvironment of TNBC by modulating M2-type macrophages.
Authors
- Dashuai Yang (ORCID: https://orcid.org/0009-0009-3157-3550)
- Han Jiang (ORCID: https://orcid.org/0000-0002-8275-4206)
- Xiaowei Yang (ORCID: https://orcid.org/0000-0002-4610-3318)
- Yuwei Xie (ORCID: https://orcid.org/0000-0001-5652-6413)
- Hong Wan (ORCID: https://orcid.org/0009-0003-4156-9981)
- Jing Pei (ORCID: https://orcid.org/0009-0000-8683-3449)
- Zichen Ling
- Zhifan Ruan
Institutions
- Anhui Medical University (CN)
- Wuhan University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1534981
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00