Jing-Yin-Gu-Biao formula protects mice from postinfluenza Staphylococcus aureus infection by ameliorating acute lung injury and improving hypercoagulable state via inhibiting NETosis
These results indicated that JYGBF inhibited NET formation and overactivated inflammatory response by suppressing ERK/ROS axis in neutrophils, thereby mitigating ALI and improving the hypercoagulable state during postinfluenza <i>S. aureus</i> infection. JYGBF could be considered a potent therapeutic agent for the prevention and treatment of postinfluenza bacterial infection.
Authors
- Guihua Xu (ORCID: https://orcid.org/0000-0001-5245-3253)
- Chunxian Zhou
- Biao Lei (ORCID: https://orcid.org/0000-0001-5255-2278)
- Lin Yuan (ORCID: https://orcid.org/0000-0002-7264-3035)
- Yuejuan Zheng (ORCID: https://orcid.org/0000-0001-9995-4960)
- Qiankun Liang
- Xiaodong Yang (ORCID: https://orcid.org/0000-0001-6895-0713)
- Yanmei Ma (ORCID: https://orcid.org/0000-0003-4290-9602)
- Liang Hu (ORCID: https://orcid.org/0000-0001-5559-3913)
- Dan Liu (ORCID: https://orcid.org/0000-0001-6168-9153)
- Wei Zhang (ORCID: https://orcid.org/0000-0002-3575-6225)
- Wenbo Huang (ORCID: https://orcid.org/0000-0003-1507-6123)
- Ting Cheng (ORCID: https://orcid.org/0000-0002-6993-1087)
- Jingwen Mu
- Lirong Xu
- Linqiong Zhou
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Shuguang Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3389/fimmu.2025.1567522
- Citations
- 7
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.58