Gut microbiota-derived metabolite phenylacetylglutamine inhibits the progression of prostate cancer by suppressing the Wnt/β-catenin signaling pathway
In summary, PAGln can effectively inhibit the proliferation, migration, and invasion of PCa by upregulating CCNG2 and suppressing the Wnt/β-catenin signaling pathway. These findings suggest that PAGln may serve as a promising therapeutic agent for prostate cancer.
Authors
- Yang Shen (ORCID: https://orcid.org/0000-0002-3313-5062)
- Chaowei Fu (ORCID: https://orcid.org/0000-0003-0966-8552)
- J P Li (ORCID: https://orcid.org/0009-0006-1798-1425)
- Ninghan Feng (ORCID: https://orcid.org/0000-0002-0892-6102)
- Jing Lv
- Yuwei Zhang (ORCID: https://orcid.org/0000-0002-8395-3020)
- Bo Liu (ORCID: https://orcid.org/0000-0003-3900-9486)
- Shengkai Jin
- Yuhua Zhou (ORCID: https://orcid.org/0009-0008-1557-963X)
- Menglu Li
Institutions
- Jiangnan University (CN)
- Nantong University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3389/fphar.2025.1528058
- Citations
- 9
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.09
Funders
- National Natural Science Foundation of China