CRSP8-driven fatty acid metabolism reprogramming enhances hepatocellular carcinoma progression by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
Our study establishes that CRSP8-driven fatty acid metabolism reprogramming facilitates HCC progression via the RAN/CRM1/PPARα nucleus-cytoplasm shuttling heterotrimer and impaired lipophagy-derived catabolism. Targeting the energy supply sourced from lipids could represent a promising therapeutic strategy for treating CRSP8-sufficient HCC.
Authors
- Yutian Chong (ORCID: https://orcid.org/0000-0001-8215-4393)
- Xiaofang Liu (ORCID: https://orcid.org/0000-0002-4687-1851)
- Zhixing Liang
- Zhiyan Weng
- Feng Zhang (ORCID: https://orcid.org/0000-0003-2887-8184)
- Yuxi Lin (ORCID: https://orcid.org/0000-0001-7210-2557)
Institutions
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13046-025-03329-3
- Citations
- 7
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 7.78