CNV-mediated dysregulation of the ceRNA network mechanism revealed heterogeneity in diffuse and intestinal gastric cancers
Driver CNV genes were identified to reveal the underlying cause of heterogeneity in DGC and IGC. Furthermore, specific driver CNV genes were identified as potential therapeutic targets, facilitating personalized treatment.
Authors
- Xi-ya Shan
- Shangwei Ning (ORCID: https://orcid.org/0000-0003-4079-8945)
- Danni He (ORCID: https://orcid.org/0000-0002-2622-3574)
- Yifan Dai (ORCID: https://orcid.org/0000-0001-7897-5228)
- Jiatong Li (ORCID: https://orcid.org/0000-0003-3778-5633)
- Mengyu Xin
- Yue Gao (ORCID: https://orcid.org/0000-0001-6330-7171)
- Bochao Xu (ORCID: https://orcid.org/0000-0002-5069-3824)
- Rongji Xu
- Jiaqi Zhou (ORCID: https://orcid.org/0000-0002-9285-8914)
- Qiuyan Guo (ORCID: https://orcid.org/0009-0007-8005-3995)
- Houxing Li
- Qian Liu (ORCID: https://orcid.org/0000-0002-0649-5951)
- Yuting He (ORCID: https://orcid.org/0000-0002-9779-6863)
- Rui Sun (ORCID: https://orcid.org/0000-0003-3537-2990)
- Peng Wang (ORCID: https://orcid.org/0000-0002-5716-9937)
- Yujie Zhang (ORCID: https://orcid.org/0000-0002-5524-2790)
Institutions
- Harbin Medical University (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s12967-025-06222-x
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Heilongjiang Province