Unveiling radiobiological traits and therapeutic responses of BRAFV600E-mutant colorectal cancer via patient-derived organoids
This study outlines the distinct radiobiological profile of BRAF<sup>V600E</sup>-mutant CRC, underscoring the critical role of radiotherapy in comprehensive treatment strategies. This work not only advances our molecular understanding of CRC but also paves the way for precision medicine, offering valuable insights for therapeutic decision-making in the clinical management of BRAF<sup>V600E</sup>-mutant CRC.
Authors
- Rong Xu (ORCID: https://orcid.org/0000-0002-5510-3678)
- Peiyuan Mu (ORCID: https://orcid.org/0000-0001-8666-5756)
- Xingfeng He (ORCID: https://orcid.org/0000-0003-2035-2516)
- Liping He (ORCID: https://orcid.org/0000-0002-1974-8962)
- Guoqiang Hua (ORCID: https://orcid.org/0000-0001-9274-8136)
- Kewen Hu (ORCID: https://orcid.org/0000-0002-0015-593X)
- Shujuan Zhou (ORCID: https://orcid.org/0000-0003-3809-7613)
- Junjie Peng (ORCID: https://orcid.org/0000-0002-0371-4960)
- Xinyue Liang (ORCID: https://orcid.org/0000-0003-4406-536X)
- Lili Huang (ORCID: https://orcid.org/0000-0003-2925-1375)
- Juefeng Wan (ORCID: https://orcid.org/0000-0001-5361-1663)
- Shaobo Mo (ORCID: https://orcid.org/0000-0002-7400-9636)
- Y. Chen (ORCID: https://orcid.org/0009-0006-9233-2572)
- Yan Wang (ORCID: https://orcid.org/0000-0002-4751-0708)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-8803-2696)
- Yaqi Wang (ORCID: https://orcid.org/0000-0002-8003-6251)
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-7825-2679)
- Xiaomeng Li (ORCID: https://orcid.org/0000-0002-7811-3457)
- Lijun Shen (ORCID: https://orcid.org/0000-0001-9459-8338)
- Ping Lu (ORCID: https://orcid.org/0009-0007-7771-3550)
- Tingting Lv
- Fan Xia (ORCID: https://orcid.org/0000-0001-8185-8663)
- Weiqing Lu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1186/s13046-025-03349-z
- Citations
- 4
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China