Molecular classification of hepatocellular carcinoma based on zoned metabolic feature and oncogenic signaling pathway
The loss of liver-specific metabolism correlates with morphological dedifferentiation, indicating cellular dedifferentiation may exhibit both physiological and pathological duality. Key signaling pathways involved in the maturation process from fetal to adult liver and zonation program may play a critical role in defining HCC diversity.
Authors
- Kazuto Nishio (ORCID: https://orcid.org/0000-0002-8275-0846)
- Kazuko Sakai (ORCID: https://orcid.org/0000-0003-1822-2720)
- Ippei Matsumoto (ORCID: https://orcid.org/0000-0003-3965-3693)
- Satoru Hagiwara (ORCID: https://orcid.org/0000-0002-3412-4701)
- Naoto Fujiwara (ORCID: https://orcid.org/0000-0002-4109-3421)
- Naoshi Nishida (ORCID: https://orcid.org/0000-0002-9111-5668)
- Masatoshi Kudo (ORCID: https://orcid.org/0000-0002-4102-3474)
- Hiroshi Ida (ORCID: https://orcid.org/0000-0002-0690-8218)
- Atsushi Takebe (ORCID: https://orcid.org/0009-0008-0506-6208)
- Masahiro Morita (ORCID: https://orcid.org/0000-0002-8627-084X)
- Masakatsu Tsurusaki (ORCID: https://orcid.org/0000-0001-9894-4912)
- Yutaka Kurebayashi (ORCID: https://orcid.org/0000-0003-3773-0851)
- Kazuomi Ueshima (ORCID: https://orcid.org/0000-0002-7577-5789)
- Tomoko Aoki (ORCID: https://orcid.org/0000-0002-9950-4553)
- Takaaki Murase (ORCID: https://orcid.org/0009-0004-7050-448X)
- Keiko Kamei (ORCID: https://orcid.org/0000-0001-8846-7120)
- Masahiro Takita
- Yasunori Minami
- Takuya Nakai
- Hirokazu Chishina
Institutions
- Kansai Medical University (JP)
- Mie University (JP)
- Keio University (JP)
- Kindai University Hospital (JP)
- Kindai University (JP)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.3350/cmh.2024.1088
- Citations
- 8
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 7.49