SARS-CoV-2 Infection of Human Lung Air-Liquid Interface Cultures Reveals Basal Cells as Relevant Targets
Collectively, our data emphasize the critical role of basal cells in facilitating SARS-CoV-2 dissemination within the upper respiratory tract and their substantial contribution to the epithelial immune response. Furthermore, our results highlight the potential of local application of Camostat mesylate as an effective strategy for inhibiting SARS-CoV-2 infection and mitigating associated immune activation early on.
Authors
- Christian Drosten (ORCID: https://orcid.org/0000-0001-7923-0519)
- Stefan Hippenstiel (ORCID: https://orcid.org/0000-0002-5146-1064)
- Andreas C. Hocke (ORCID: https://orcid.org/0000-0002-6935-8612)
- Katja Hönzke (ORCID: https://orcid.org/0000-0003-0826-2825)
- Anna Löwa (ORCID: https://orcid.org/0000-0002-5551-731X)
- Anita Balázs (ORCID: https://orcid.org/0000-0002-1402-5239)
- Benedikt Obermayer (ORCID: https://orcid.org/0000-0002-9116-630X)
- Luiz Gustavo Teixeira Alves (ORCID: https://orcid.org/0000-0002-5822-4168)
- Morris Baumgardt (ORCID: https://orcid.org/0000-0003-2077-3716)
- Marcus Alexander Mall (ORCID: https://orcid.org/0000-0002-4057-2199)
- Markus Landthaler (ORCID: https://orcid.org/0000-0002-1075-8734)
- Katharina Hellwig
- Dieter Beule (ORCID: https://orcid.org/0000-0002-3284-0632)
- Emanuel Wyler (ORCID: https://orcid.org/0000-0002-9884-1806)
- Marcel A. Müller (ORCID: https://orcid.org/0000-0003-2242-5117)
Institutions
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- German Center for Infection Research (DE)
- German Centre for Cardiovascular Research (DE)
- German Center for Lung Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Institute of Virology of the Slovak Academy of Sciences (SK)
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1093/infdis/jiaf125
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52