Macrophage-Specific Progranulin Deficiency Prevents Diet-Induced Obesity through the Inhibition of Hypothalamic and Adipose Tissue Inflammation
Macrophage-derived PGRN and possibly other Grn products play a critical role in the development of HFD-induced obesity, tissue inflammation, and impaired hormonal signaling in both central and peripheral metabolic organs.
Authors
- Won Hee Jang
- Hyun-Kyong Kim
- Chan Hee Lee (ORCID: https://orcid.org/0000-0001-8791-817X)
- Jae Bum Kim (ORCID: https://orcid.org/0000-0003-2337-6935)
- Chae Beom Park (ORCID: https://orcid.org/0000-0002-8384-617X)
- Min‐Seon Kim (ORCID: https://orcid.org/0000-0002-4881-0390)
- Se-Hee Min (ORCID: https://orcid.org/0000-0002-0945-0177)
Institutions
- Ulsan College (KR)
- Seoul National University (KR)
- Hallym University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-03-11
- DOI
- https://doi.org/10.4093/dmj.2024.0486
- Citations
- 6
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 8.34