Ermiao San attenuating rheumatoid arthritis via PI3K/AKT/mTOR signaling activate HIF-1α induced glycolysis
The beneficial effects of EMS in CIA rats can be attributed to the inhibition of glycolysis in synovial fibroblasts via the PI3K/AKT/mTOR/HIF-1α pathway. This finding further enriches our understanding of the mechanisms by which EMS contributes to the treatment of RA.
Authors
- Shuyan Xue
- Yuqi Liu (ORCID: https://orcid.org/0000-0001-6021-0059)
- Haizhu Jin (ORCID: https://orcid.org/0000-0003-3542-9184)
- Jia Wei (ORCID: https://orcid.org/0000-0002-9634-9439)
- Yumeng Zhang (ORCID: https://orcid.org/0000-0001-5220-0491)
- Huiqin Hao
- Yang Liu (ORCID: https://orcid.org/0000-0003-4350-8448)
- Yuru Wang (ORCID: https://orcid.org/0000-0002-2309-1043)
Institutions
- Shanxi University (CN)
- Jinzhong University (CN)
- Shanxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1016/j.jep.2025.119615
- Citations
- 10
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.97