Relationship Between Post Covid 19 Duration and Biomarkers: A Retrospective Study in Hospitalised Patients

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), now known as coronavirus disease 2019 (COVID-19) were initially reported in Wuhan, China and rapidly spread throughout world in December 2019. The present retrospective study was postulated to assess the relationship between the post COVID 19 duration and biomarkers. Methods: About 369 subjects diagnosed as COVID-19 infection confirmed by “Nasopharyngeal Reverse Transcription Polymerase Chain Reaction (RT-PCR) positive for SARS-CoV2” of all disease severity and admitted to Viveka Hospitals, Nagpur, Maharashtra, INDIA were included in the study. The laboratory investigations viz., D-Dimer, ferritin and C-reactive protein (CRP) and Lactate dehydrogenase (LDH) recorded at the time of admission, after 15th day and 30th day of discharged were retrieved from the hospital records. The relationship was computed using Paired t test and the confidence interval was set at 95%. The study was initiated after approval from the Institutional Ethics Committee of Viveka Hospitals, Nagpur, with Reg. No. ECR/1639/INST/MH/2021, Dated 20th Feb 2024. Results: The mean D Dimer and ferritin values showed significant (p = 0.000) decrease after 15 days of discharge and CRP and LDH showed insignificant (p>0.05) increase and decrease respectively as compared to day of admission. After 30th days of discharge D Dimer increased significantly (p = 0.000) and ferritin and CRP decreased insignificantly (p>0.05). Conclusion- It can be concluded from the study that COID19 biomarkers responds differently after 15th and 30th days of discharge. The suitable changes in medical protocols after 15th day and 30th days of discharge can reduce morbidity amongst the COVID 19 patients.