Comparative Trial of Furosemide-Spironolactone Combination and Furosemide-Metolazone Combination in Treating Refractory Edema in Nephrotic Syndrome Patients

Introduction: Nephrotic syndrome is defined as the presence of nephrotic range proteinuria, hypercholesterolemia, and generalized edema. Proteinuria that is more than 85% albumin is selective proteinuria. Albumin has (-ve) charge, and it is loss of glomerular membrane (-ve) charges could be significant in causing albuminuria. Objective: Comparison of Furosemide-Spironolactone Combination and Furosemide-Metolazone Combination in Treating Refractory Edema in Nephrotic Syndrome Patients. Materials and methods: This was a cross-sectional study design of six month from December 2023 to May2024. Results: The mean Age of the patients enrolled for the study with the minimum age being 1 year and maximum age being 14 years and the mean age was 5.6 years. It shows that weight loss at day 4 and 5 was significantly higher in group B as compared to group A. Conclusions: Group B patients having lower mean abdominal girth as compared to group A. Mean Serum electrolyte values like S.Na+, S.K+, S.Ca+ of both the groups were compared and found to be similar thus highlighting that both the combinations had similar effects in the patients with respect to electrolyte abnormalities.