Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy
Taken together, our data suggest that Obsc and Obsl1 play crucial roles in cardiac sarcoplasmic reticulum structure, calcium cycling, mitochondrial function, turnover, and metabolism.
Authors
- Meenu Rohini Rajan (ORCID: https://orcid.org/0000-0003-3900-1206)
- M Kłos
- Emma Börgeson (ORCID: https://orcid.org/0000-0002-2290-9472)
- Majid Ghassemian (ORCID: https://orcid.org/0000-0003-1026-5152)
- Yunghang Chan
- Yusu Gu (ORCID: https://orcid.org/0000-0002-9543-8472)
- Nancy D. Dalton
- Jordan Blondelle (ORCID: https://orcid.org/0000-0003-4755-728X)
- Matúš Soták (ORCID: https://orcid.org/0000-0002-9984-9340)
- É. Estève (ORCID: https://orcid.org/0000-0002-4548-9140)
- Virginia Actis Dato (ORCID: https://orcid.org/0000-0002-9071-8045)
- Kyohei Fujita (ORCID: https://orcid.org/0000-0001-8724-3096)
- Stephan Lange (ORCID: https://orcid.org/0000-0001-9361-6602)
- Aryanne Do
- Madison Clark (ORCID: https://orcid.org/0000-0002-0156-3513)
- Farah Sheikh (ORCID: https://orcid.org/0000-0003-2610-0125)
- Valeria Marrocco (ORCID: https://orcid.org/0000-0003-2516-3511)
- Yoshitake Cho (ORCID: https://orcid.org/0000-0002-7161-3248)
- Patrick Desmond
- Kirk L. Peterson
Institutions
- Centre National de la Recherche Scientifique (FR)
- Steno Diabetes Centers (DK)
- Inserm (FR)
- Aarhus University (DK)
- Sahlgrenska University Hospital (SE)
- University of California San Diego (US)
- Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR)
- Tokyo Women's Medical University (JP)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1161/circheartfailure.124.011867
- Citations
- 3
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 4.16