<i>Plasmodium falciparum histidine-rich protein 2/3</i> gene deletions and repeat motifs in Chhattisgarh, India (2017–2018)
The results indicate that the deletion rates and sequence diversity of Pfhrp2 and Pfhrp3 in Chhattisgarh are below the WHO threshold of 5% for a policy change regarding Pfhrp2 gene deletion. Sequence diversity does not appear to compromise the performance of current PfHRP2-based RDTs. However, a larger-scale study encompassing other endemic regions of India is recommended for a more comprehensive understanding of the impact on RDT efficacy over time.
Authors
- Kanika Verma (ORCID: https://orcid.org/0000-0002-5676-0899)
- Shrikant Nema (ORCID: https://orcid.org/0000-0003-0296-8296)
- Anil Verma (ORCID: https://orcid.org/0000-0002-3105-4138)
- Praveen Kumar Bharti (ORCID: https://orcid.org/0000-0003-2548-4884)
- Monika Kumari (ORCID: https://orcid.org/0000-0003-0398-1169)
- Anup Anvikar (ORCID: https://orcid.org/0000-0001-8455-6054)
- Aparup Das (ORCID: https://orcid.org/0000-0002-4081-5816)
- Sri Krishna
- Venkatachalam Udhayakumar
- Nazia Ali (ORCID: https://orcid.org/0000-0001-6638-0649)
Institutions
- National Institute for Research in Tribal Health (IN)
- The Task Force for Global Health (US)
- National Institute of Malaria Research (IN)
Publication Details
- Journal
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1093/trstmh/traf029
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76