CREB1/CRTC2 regulated tubular epithelial-derived exosomal miR-93-3p promotes kidney injury induced by calcium oxalate via activating M1 polarization and macrophage extracellular trap formation
CaOx crystals exacerbate renal interstitial injury by promoting M1 macrophage polarization and METs formation through the CREB1/CRTC2-exosomal miR-93-3p-NIK/NF-κB2 signaling pathway. Targeting this pathway may provide therapeutic avenues for mitigating crystal deposition-induced kidney damage.
Authors
- Ting Rao (ORCID: https://orcid.org/0000-0001-8915-4855)
- Xiangjun Zhou (ORCID: https://orcid.org/0000-0001-7480-507X)
- Yuqi Xia (ORCID: https://orcid.org/0000-0001-8827-7933)
- Baofeng Song
- Cheng Fan (ORCID: https://orcid.org/0000-0002-3471-6221)
- Fangyou Lin (ORCID: https://orcid.org/0000-0001-7369-7855)
- Bojun Li (ORCID: https://orcid.org/0000-0001-7471-7897)
- Yushi Sun
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12951-025-03246-9
- Citations
- 7
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 10.02
Funders
- National Natural Science Foundation of China