Prevalence and impact of antisperm antibodies on semen quality and male reproductive health aspects: A 10‐years retrospective study

In this study, data on ASA prevalence, impact in semen quality and on several aspects of male reproductive health were analyzed in one of the biggest and thoroughly characterized cohorts so far. Agglutination and impaired motility remain the most revealing parameters of ASA presence and should be considered in the clinical ASA management. Interestingly, we are the first to report an association between smoking and pathological ASA levels. The reported higher testicular volume and lower FSH in ASA patients may be of clinical relevance, suggesting that ASA might also have a role in the impaired fertility, highlighting the importance of ASA testing especially in men with lacking etiologic factors.