Cyclopropane Containing Triterpenoids, Cycloartenone, and Cycloartenol: Isolation, Chemical Transformations, and Anticancer Studies

Abstract Cycloartenone and cycloartenol, two plant‐derived triterpenoids possessing cyclopropane ring were isolated from the latex of Artocarpus heterophyllus (jackfruit). Cycloartenol was chemically modified to synthesize dihydrocycloartenol via acetylation and deacetylation methodology followed by hydrogenation. Hydroxyl group present in the cycloartenol was also employed for the nitro benzoate formation. All the isolated and synthesized compounds were assayed against MCF7 breast cancer cell line for their anticancer properties.

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Publication Details

Journal
ChemistrySelect
Published
2025-03-01
DOI
https://doi.org/10.1002/slct.202403698
Citations
1
Primary Topic
Plant biochemistry and biosynthesis
Type
article
Field-Weighted Citation Impact
0.81
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article

Cyclopropane Containing Triterpenoids, Cycloartenone, and Cycloartenol: Isolation, Chemical Transformations, and Anticancer Studies

Kartik Mandal, Sayantan Paul, Manas Kumar Santra, Asish K. Bhattacharya
1 citations
ChemistrySelect
Plant biochemistry and biosynthesis
0.81
article

Cyclopropane Containing Triterpenoids, Cycloartenone, and Cycloartenol: Isolation, Chemical Transformations, and Anticancer Studies

Kartik Mandal, Sayantan Paul, Manas Kumar Santra, Asish K. Bhattacharya
article en
1 citations

Abstract

Abstract Cycloartenone and cycloartenol, two plant‐derived triterpenoids possessing cyclopropane ring were isolated from the latex of Artocarpus heterophyllus (jackfruit). Cycloartenol was chemically modified to synthesize dihydrocycloartenol via acetylation and deacetylation methodology followed by hydrogenation. Hydroxyl group present in the cycloartenol was also employed for the nitro benzoate formation. All the isolated and synthesized compounds were assayed against MCF7 breast cancer cell line for their anticancer properties.

ChemistrySelectVol. 10(9)
National Chemical Laboratory (IN), National Centre for Cell Science (IN), Academy of Scientific and Innovative Research (IN)
Openalex Percentile: Top 30%
Plant biochemistry and biosynthesis
0.81
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Cyclopropane Containing Triterpenoids, Cycloartenone, and Cycloartenol: Isolation, Chemical Transformations, and Anticancer Studies — Kartik Mandal, Sayantan Paul, et al. · ChemistrySelect (2025) | TGRS Research Map | TGRS