Cyclopropane Containing Triterpenoids, Cycloartenone, and Cycloartenol: Isolation, Chemical Transformations, and Anticancer Studies
Abstract Cycloartenone and cycloartenol, two plant‐derived triterpenoids possessing cyclopropane ring were isolated from the latex of Artocarpus heterophyllus (jackfruit). Cycloartenol was chemically modified to synthesize dihydrocycloartenol via acetylation and deacetylation methodology followed by hydrogenation. Hydroxyl group present in the cycloartenol was also employed for the nitro benzoate formation. All the isolated and synthesized compounds were assayed against MCF7 breast cancer cell line for their anticancer properties.
Authors
- Kartik Mandal (ORCID: https://orcid.org/0000-0002-5319-1918)
- Sayantan Paul (ORCID: https://orcid.org/0000-0001-7731-9237)
- Manas Kumar Santra (ORCID: https://orcid.org/0000-0002-8899-4518)
- Asish K. Bhattacharya (ORCID: https://orcid.org/0000-0002-9162-522X)
Institutions
- National Chemical Laboratory (IN)
- National Centre for Cell Science (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/slct.202403698
- Citations
- 1
- Primary Topic
- Plant biochemistry and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81