FeI2-Promoted Dehydrative Coupling and Iodocyclization Reaction of 4-Hydroxycoumarins and Propargyl Alcohols for the Synthesis of Chromone Derivatives
Abstract The reaction of 4-hydroxycoumarins with propargyl alcohols was studied by using FeI2. Chromone derivatives were obtained by a FeI2-promoted sequential transformation involving dehydrative coupling followed by iodocyclization. The FeI2-mediated iodocyclization of the coupling intermediates proceeded in a regioselective 6-endo-dig manner to give the chromone derivatives without the formation of coumarin derivatives.
Authors
- Yousuke Yamaoka (ORCID: https://orcid.org/0000-0003-3641-8823)
- Eito Yoshioka
- Ayaka Yamada (ORCID: https://orcid.org/0000-0001-9203-0474)
- Hideto Miyabe (ORCID: https://orcid.org/0000-0001-7587-9329)
- Reiko Tanaka (ORCID: https://orcid.org/0000-0003-0008-3996)
- S. Matsuyama
- Iori Tokunaga
Publication Details
- Journal
- Synthesis
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1055/a-2556-3032
- Primary Topic
- Synthesis of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00